Toxicity Assessment of Ethanolic Extracts of Amaranthus Spinosus L., in Wistar Rats Using OECD 407 Guidelines

Abstract

The various parts of Amaranthus spinosus (Amaranthaceae) extracts have the following activity viz. analgesic, antiinflammatory antidiabetic, antihyperlipidemic, antimalarial  and antioxidant properties; antiprotozoal, hepatoprotective, immuno-modulatory and spermatogenic effects Despite its potential therapeutic uses, the toxicity profile of Amaranthus spinosus has not been evaluated. This study assessed the sub-acute toxicity effects of whole plants of Amaranthus spinosus ethanolic extract (ASE). The sub-acute toxic effect of the ASE (1000 mg/kg) was investigated by administration for 28 consecutive days as per the OECD 407 guideline. The weekly body weights were recorded. The animals were euthanized on the 29^th day, and blood samples were obtained for the hematological and biochemical investigations. The kidney and uterus were subjected for histological examinations.