Special Opinion on the Dependence of the Birth of Children with down Syndrome on the Age of Their Parents

Abstract

The problem of prenatal diagnosis of Down syndrome is one of the most urgent problems in modern obstetrics. The paper analyzes and studies the effectiveness of prenatal diagnosis of Down syndrome in Uzbekistan, cities in West Africa, North and South America, Eastern and Western Europe, Southeast Asia and South Asia for 2008-2011, taking into account the age of women who gave birth to healthy children and children with Down syndrome. In contrast to developed countries, in developing countries, the peak birth rate is at the age of 22-26 years, the birth rate for women under 35 years is higher and on average is 80% compared to women over 35 years – 20%. The number of registered fetuses with trisomy 21 in women under 35 years of age is 4 times higher than in older women. When computation the risk of having a child with Down syndrome in a woman over 35 years of age increases significantly, compared with women under 35 years of age. Our research confirms that the highest percentage of births of children, both with Down syndrome and children without genetic pathology, occur in the age period from 20 to 35 years. Therefore, the expediency of complex use of biochemical and ultrasound screening in the first and second trimesters of pregnancy, regardless of age, for the purpose of effective prevention of chromosomal diseases and, above all, Down syndrome, is noted.