Evaluation of Biochemical Parameters on Tobacco Chewers in Different Age Related Groups
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Abstract
ABSTRACT
Background: Tobacco chewing and alcohol abuse are accepted as ‘two-hit’ hypothesis of cardiac arrest and liver disease. However, there are few research articles on identifying genes which connect lipid and glucose metabolism by liver markers enzymes.
Objectives: To diagnoses of alcoholic liver disease were made based on the combination of history of tobacco chewing, alcohol abuse and increased levels of liver enzymes, in the absence of other causes for liver disease.
Methods: To analyse the human serum marker enzymes of alcoholic fatty liver disease was established by different habit human samples estimate the expression of liver marker enzymes were determined using the automatic biochemical analyser.
Results Blood glucose levels were significantly increased and may be due to hyperglycemia in blood system. Protein levels were moderately decreased, indicating rate of protein catabolism in tobacco chewers. Urea levels were increased due to increase rate of protein catabolism this inturn lead to increased excretion of urinary nitrogen. Level of creatinine are increased may be due to the reduction of muscle mass during aging. Elevated levels of uric acid were due to hyperuricemia. Cholesterol levels were significantly enhanced whereas HDL cholesterol was significantly decreased in tobacco chewers. The increasing serum cholesterol may be due to increased LDL and VLDL.
Conclusions: Chewing tobacco could result in significance greater deleterious cardiovascular effects due to cholesterol, glucose, LDL and low HDL cholesterol in tobacco user as compared to tobacco non – user.