Analysis Of Dental Caries Pathogenesis By Genomic and Metagenomic Approach

Abstract

The microbiome investigation into dental caries is usually based on 16S rRNA arrangements testing, which is concerned with precise consideration of PCR possibilities, low-order targets, and capabilities. Here, we used whole metagenome shotgun sequencing  in conjunction with high-resolution test calculations, which could integrate superimposed microbiomas from 30 children with or without dental caries. A sum of 726 bacterial strains having a place with 406 animal groups, notwithstanding 34 bacteriophages were distinguished. One center was distinguished by bacterium species and strain levels. Types of Prevotella, Veillonella, up 'til now anonymous Actinomyces, and Atopobium indicated most grounded relationship with caries; Streptococcus sp. AS14 and Leptotrichia sp.