Isolation and biological evaluation of thiazole ethanol derivative secondary metabolite from marine derived fungus Aspergilliusterreus

Abstract

Marine derived products have been promising sources for the detection of unique bioactive compounds and gaining importance for their biotechnological applications. Aspergillus terrus was isolated from the marine sample by serial dilution and the novel basal media formulated in this study resulted in the synthesis of the fungal secondary metabolite. The structure of the bioactive secondary metabolite was analyzed by ¹H-, ¹³C-NMR and mass spectral data as 1-(4,6-dihydro-2-vinylfuro[3,4-d] thiazol-6-yl)ethane-1,2-diol. Different concentrations of the compound (250,500,750 & 1000µg/ml) were prepared and tested against the test microorganisms using well diffusion method showed strong inhibitory activities. IC₅₀ value of the compound was 1.24mg/ml, suggesting a strong antioxidant activity and the DPPH radical scavenging ability of the compound was significantly lower when compared to that of ascorbic acid.