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To analyze the benefit of using intralesional Measles, Mumps and Rubella vaccine (MMR) for patients with multiple warts.50 Subjects of age groups >8 years of age, with multiple warts who has not undergone treatment for the past 6 months were chosen and given intralesional MMR, a quantity of 0.5ml is given in the largest wart among the multiple warts. A maximum of upto5 injections can be given in an interval of 2 weeks. Follow up was made every 2 weeks for 6 weeks and then monthly once for 6 months to detect any recurrence. Complete responsewas seen in 36 (72%), partial response in 8 (16%) and no response in 6 (12%) were observed.Intralesional Immunotherapy with MMR vaccine was found to be simple, effective and safe treatment for multiple warts. This treatment proved to be cost effective for the patients as well as chance of recurrence is less compared with other treatment modalities.