Physiological Changes of Some Biochemical Parameters in Blood, Liver and Kidney Result by used Antibiotic Cefixime

Abstract

In the present, using of antibiotics frequently in the treatment of many acute and chronic diseases common to be wide especially in the Middle East. Most of these diseases are frequent and require treatment daily for long and frequent periods. Cefixime, one the antibiotic medicine, it belong to the third-generation of cephalosporin family-like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes and is widely used to treat cold or against influenza virus. The results of this study were shown that the treatment of male of rats with Cefixime in the usual, double and excessive therapeutic dose led to no significant differences (P ≤ 0.05) in the level of RBCs and Hb when compared with the control group. There is a simple significant increase in the level of WBCs in male of rats treated with Cefixime in the usual, double, and excessive therapeutic doses compared with the control group. About liver function parameters,the result showed a group of significant differences (p≤0.05) in the liver enzymes (ALT, ALP, and AST) which present in a significant increase in the level of ALT, ALP, and AST in the group of double and excessive doses, while it was no significant difference in the level of ALT and AST in the group of usual or normal dose when compared with the control group. As for the kidney factors Creatinine, Urea, Sodium, and Potassium the result shown no significant differences(p≤0.05) in levels of Creatinine and Urea in groups (normal), double, and excessive doses when compared with the control group. The current study found that a short course of Cefixime therapeutic treatment normal, double, and excessive doses had no effects on blood, liver, and kidney studying parameters.