The Relationship between Some Immunological Criteria and Women with Recurrent Miscarriages

Abstract

The aim of this study is to determine the relationship between certain immunological parameters and recurrent miscarriages (RM) at first trimester among women patients with a past history of RM that associate with antiphospholipid syndrome (APS), as well as, know the positive prevalence of autoantibodies(IgM) in patients compared with healthy women .The study enrolled 88 women including,55 aborted women in the first trimester of gestation with a history of RM, and 33 were selected as a control group , who attend the emergency and consulting divisions in maternity and pediatrics hospital at Babylon province, where their ages ranged between eighteen to thirty-five year. Sera from all participants were tested to assessment of some immunological parameters related to this study. It was observed that a high positive prevalence of IgM anti β2-glycoprotein I(aβ2GPI) which reached 50.0% in comparison with 21.6% and 18.2% to an index value of IgM for antiphospholipid(aPL) and anticardiolipin (aCL) respectively.The odds ratio (OR) for IgM aβ2GPI was 50.08 % ,whereas it was 6.93 % & 5.29 % for aPL and aCL IgM respectively, at a level of significant difference (P< 0.05).Also, the results showed a non-significant difference (P = 0.070) in the mean concentration of anti-thrombin III (AT III) in the sera of aborted women (58.60 ± 13.87 ng/ml), compared with healthy women (53.39 ± 11.09 ng/ml) , in addition the levels of CD56/ NCAM1 and IL-17A were higher in aborted women (129.15±11.60 pg/ml; 52.65±4.83 pg/ml) compared with a healthy subjects (92.42±8.32 pg/ml; 23.09±4.90 pg/ml).The ROC (Receiver Operating Characteristic) curve was employed to evaluate the prevalence of IgM for the parameters of APS, where was good to excellent in the degree of accuracy for all IgM in relying on the area under the curve (AUC). On the other hand, the sensitivity of aCLIgM and aPL IgM were 89.09% (95% CI 77.8-95.9) and 87.27% (95% CI 75.5-94.7) respectively , whereas the sensitivity of aβ2GPI IgM was 74.55% (95% CI 61.0-85.3), so it was the lowest among them.