Antibiotic Resistance Pattern to Pseudomonas Aeruginosa Isolated from Different Sample

Abstract

Aim: The P. aeruginosa has become an important and frequent opportunistic nosocomial pathogen. Antimicrobial managers are often classified according to their principal mechanism of action. This study analysis the infections caused by Ps. aeruginosa  and try to reveal the antimicrobial agents susceptibility against Ps. aeruginosa.

Material and Method: A cross-sectional study was carried out in different specimens (urine, sputum,tooth) were collected from Public Health Laboratory and private clinic lab, which transferred by using media or swab media between (  October   2020 to 30 march 2021 ).

A total 50 P. aeruginosa isolates were obtained from 157 clinical samples.. Were (29, 58%) from urine ,(19, 38%)from sputum and (2, 4%) from tooth. These isolates were identified according to the traiditianal and molecular technique, such as culture and microscopic examination, biochemical tests, API 20E kit, Vitek2 system, and PCR

Result: In present study, isolates of  Ps. aeruginosa  isolated from various samples (29, 58%) urine ,(19, 38%) sputum and (2, 4%) from tooth. It was found out that ( 24.14% male  and 75.86% female  in urine sample ) , (36.85% male and 63.15% female in sputum sample ) and (50% male and 50% female in tooth sample ),  For Pseudomonas aeruginosa the highest resistance percentages were found to Ampicillin, ceftriaxone, Imipenem, ,Gentamicin, norfloxacin, levofloxacin, Ciproflaxin, Amikacin, cefoxitin, and the lowest level of antibiotics was pipracillin .

Conclusion: Steady educational programs on infection control for all healthcare workers to stop the range of nosocomial infections.the antidrug resistance will continue to be a problem  with Pseudomonas spp. infections, there is an immediate need to replace these antibiotics with developing treatment strategies, to avoid and to exclude the infections.