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Aims: The study aims at assess nurses' knowledge towards infection control for patients with fracture. Methodology: A descriptive study used assessment approach with questionnaire items is conducted to explore nurses knowledge. By a purposive random sample of (100) nurses is selected throughout the use of non-probability sampling approach. Data was collection through the use of a questionnaire and self-report nurses. Through the application the descriptive statistic, data were analyzed. Results: According to the analysis mean of score, the findings indicate that the majority (53%) of nurses knowledgeable at mean +S.d.= 2.46+0.626. As well as, the findings indicate that the majority (55%) of nurses poor knowledge regarding fracture ward and waste management at low level of mean +S.d.= 1.46+ 0.521. Conclusion: Knowledge in terms of personal protective equipment, nurses were knowledgeable. Knowledge in terms of fracture ward & waste management, nurses were poor knowledge. More years of experience and training the staff on orthopedic wards by local officials help raising professionals’ nurses' knowledge. Provide the health resources and exploiting young energies of nurses which indeed helps to develop their knowledge and practice.