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Alzheimer's disease is the most common form of dementia and gradually affects the elderly. The disease is associated with toxic chemicals of industrial origin. Based on neurotoxic studies showing that heavy metals induce Alzheimer’s disease, this paper discusses potential effect of several heavy metals with Alzheimer’s disease infection. Where the study included 42 patients suffering from Alzheimer's disease after confirming their diagnosis of the disease and 30 cases as health controls. Concentrations of many heavy metals (lead, cadmium, mercury, iron, zinc and aluminum) were determined in the blood samples of patients and healthy subjects, as the detection of the content of the concentration of these minerals showed high levels in patients compared to healthy controls, and the analysis of the variance of the mineral content of the patients showed high significant effects (P <0.01) Compared to healthy people.