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The current study aimed to evaluate effects of Ketamine, Xylazine and their combination on liver and kidney features parameters in male rabbits (age 4-5 months) were divided in to three groups (6 rabbits / group). Group 1 (control): six adult males' rabbit's injection distal water (1 ml), Group 2 (K+Z/M): six adult male rabbit's injection ketamine (35 ml) combination with xylazine (5 ml) intramuscular (I/M).Group 3 (K+Z/V): six adult male rabbit's injection ketamine (6 ml) combination with xylazine ( 0.6 ml) intravenously (I/V). Group 4 (Z- after 10 min given K): six adult male rabbit's injection xylazine (5 ml) and then after 10 min injection ketamine ( 35 ml) intramuscular (I/M). At end of treatment. Body weight (BW) of animals, as initial and final of administration were recorded. Plasma biochemical and liver enzymes are taken for analysis at the end of treatment. Results appeared ALT and AST concentrations increased in G4 (Z- after 10min given K) while significantly decreased in G2 but ALP concentrations significantly increased in G2 and G4 as compared to other treated groups. The data of ureaand concentrations of BUNand creatinine increment in group G4 but decreased in G2 than other groups in experiment, all groups showed significantly differences in TP. In this study; the results showed that combinations of ketamine and xylazine could be used in anesthesia practice in laboratory animals.