Evaluation and Correlation Analysis of Serum High Sensitivity C - reactive protein and Lipid Profile among Hypertensive Patients: a Cross-Sectional Study

Abstract

Hypertension and dyslipidemia are the two most significant healthanxieties and major risk factors for cardiovascular diseases. It has been reported that chronic inflammatory disorder is the root causes of hypertension and elevated levels ofserum high-sensitivity C-reactive protein (hsCRP).A laboratory based comparative cross-sectional case-study was conducted from November 2017 to April 2018. A total of 100 participants, 57 hypertensive patients, and 43 normal controls were recruited. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, hsCRP, and lipid profiles.The elevated levels of serum hsCRP(p<0.001), triglycerides, and total cholesterol were observed in both sexes of hypertensive patients (p<0.05). However, the serum levels of high-density lipoprotein and low-density lipoprotein showed only numerical differences but not statistically. The hsCRP was positively correlated with triglycerides, total cholesterol, and inversely correlated with serum high-density lipoprotein. The significant changes in hsCRP may suggest that inflammation might be associated with hypertensive
patients. Measurement of hsCRP at regular intervals may be used for a prognosticmarker for disease severity.