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Background: Platelet morphology plays a key role in occurrence and may determine prognosis in acute ischemic stroke.Aims and objectives: To assess the relation of mean platelet volume and plateletcrit with outcome in acute ischemic stroke.Material and methods:The study was conducted in 100 patients with acute ischaemic stroke in a tertiary care hospital.Study Design: This was a prospective, observational and non interventional study conducted on cohort of patients with Acute ischemic stroke in tertiary care teaching hospital, over period of 6 months. The Institutional Ethical committee approval was taken. All enrolled patient underwent platelet indices platelet count, mean platelet volume and plateletcrit (PC, MPV, PCrt) , haemoglobin, Serum creatinine, fasting Lipid profile, Blood sugar level, HbA1c, modified Rankin Scale (mRS) and Brain imaging study (CT scan or MRI).Statistical Analysis: Data was analysed for mean, percentage, standard deviation and chi square test for quantitative data. Appropriate statistical tests were applied using SPSS software version 21 (trial version) for analysis and ‘p’ value <0.05 was considered statistically significant. Results:Total 57 (57%) were males and 43 (43%) female fulfilling enrolment criteria were included in present study. The mean of platelet count in present cohort was 248.4 (SD±93.64), mean of mean platelet volume was 8.247 (SD±1.41) and the mean of plateletcrit was 0.20 (SD±0.08). The mean of modified Rankin Scale in present cohort was 3.11 (SD±1.22). The MPV had positive correlation with age (0.23), triglycerides (0.08), glycosylated haemoglobin (0.26) and modified Rankin scale (0.64). Platelet count had positive (0.13) correlation with total cholesterol, low density lipoprotein (0.10), high density lipoprotein (0.22) and glycosylated haemoglobin (0.26).Plateletcrit had positive (0.14) correlation with total cholesterol, low density lipoprotein (0.10), high density lipoprotein (0.19), glycosylated haemoglobin (0.39) and Modified Rankin scale (0.25). Conclusion: Acute ischemic stroke was significantly associated with raised MPV level, which is likely to be severe with high Modified Rankin scale score. Raised MPV level can be used as surrogate marker in patient with AIS along with other risk factors.