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A 36-year-old female patient, housewife, experienced neck pain on the left side than on the right side, but more pain on the left side since last three months. The pain was characterized by a sudden onset, trigger point aggravated with limitation in range of motion with cervical flexion and painful rotation on the left side.The muscle is activated, and due to heavy work load and constant standing work, muscle stiffness is altered. So, the patient had a pain reaction that was radically different. In this study, recovery focused more on myofascial release and manual therapy and focused more on pain neuroscience education [PNE].Simply taking care of different causes of muscle induced neck pain, including myofascial pain syndrome, can significantly aid in the selection of an effective treatment plan. In this case, where neck pain is accompanied by active trigger points in muscles, manual therapy and the main focus of the pain biopsychological model in on pain neuroscience education, the comprehension of pain experiences or positive outlook on lifeand we have shown that kinesio-phobia, pain anxiety, and pain perceptions regarding pain control, physical harm, and drugs, and psychosocial characteristics can be reduced by PNE.