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A series of pyrazoline derivatives were synthesized by reaction furan-2-yl methyl (sulfanyl) acetic acid hydrazide with chalcone dibromides. The later was synthesized by grinding the different aldehydes with different ketones without using any solvent after that addition of bromine to produce the desired in the presence of sodium hydroxide. all compounds were confirmed by FT-IR, H-NMR and 13C-NMR.All these pyrazoline compounds were tested for antibacterial and antifungal activities. Some compounds show very antibacterial activity and antifungal activity.