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Introduction-When a susceptible host is infected, the symptoms start after an incubation period of 3 to 14 days. The mosquito gets infection from the infected host when it feeds on the host. There is a global resurgence of Dengue fever as a result of population explosion, unplanned urbanization as well as due to lack of effective mosquito control measures. The Dengue virus is transmitted by the Aedes mosquito. Since the early 20th century when experiments showed that Dengue virus was transmitted by Aedes Aegypti.The Aim here is to assess the relation of proteinuria with severity of Dengue Fever. The method that we have adopted for our researchresearchis Hospital-based Cross-sectional Observational Study. The Study duration was 18 months (1st October 2018 to 31st March 2020). Result indicate significant association was seen in occurrences of abdominal pain, nausea, joint pain, edema and altered sensorium in Dengue patients with proteinuria.The study concludes that it is important to look for proteinuria in Dengue patients at the earliest for detecting the severity of Dengue and to avoid any further complications related to renal involvement in Dengue.