The Role of the Hormone Apelin and Some Biochemical Variables in Patients with Kidney Stones

Abstract

There is a significant correlation between kidney stones, type of food, environment, and the variety of medication taken, as well as genetic conditions, as well as the effect of the level of electrolytes on the formation of stones. This study was conducted in the laboratories of Kirkuk General Hospital and the Public Health Laboratory in Kirkuk Governorate from 1/12/2019 to 1/1/2021. , Where the study included (60) samples of people with kidney stones ranging in age from (30-72) years, the number of men (32) men and the number of women (28) women, as well as (30) blood samples were collected from healthy people, where the number of men was (15) men and the number of women was (15) women, and they were chosen randomly from the residents of Kirkuk governorate.

This study also includes some biochemical variables: levels of the hormone apelin, aldosterone, and measuring the sodium ion (Na⁺), calcium ion (Ca⁺⁺), and body mass index. In addition to studying the relationship of ages and studying the number of times the formation of stones and gender, and comparing it to the control group.

There were no significant differences between patients with kidney stones and the control group in their effect on the level of the hormone apelin, the results also showed that there was no significant difference in the levels of apelin in all the studied factors. It was also noted that there was a significant decrease (p <0.0001) in the levels of the hormone aldosterone among the group of patients with kidney stones for the age groups of patients. There is a decrease in the age group (30-49) compared to the age group (50-72). For patients, also a significant decrease (p <0.0001) was found in the levels of the hormone aldosterone among the group of patients with kidney stones who had stones for the first time compared to the group of patients who had stones more than once, while there was no significant increase in patients for the rest of the variables studied in This study, as for calcium, the results showed that there were no significant differences between kidney stone patients and the control group, as well as no significant difference for the rest of the variables studied in this study. As for sodium, there was a significant decrease (p <0.0001) in the blood serum of patients with kidney stones compared to the control group, as well as a significant decrease (p <0.0001) in the blood serum of patients with kidney stones in the age group (50-72) compared with the age group (30). -49), Also, there was a significant decrease (p <0.0001) in the blood serum of kidney stone patients for patients who had stones more than once compared to patients who first formed them. There was no significant difference for the rest of the variables studied in this study.