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. The development in the drug industry stimulates the phytotherapy applications with the advance of research about the active constituents in plants exhibit that use of them in traditional medicine4, such Punica granatumL.(pomegranate) plant. This study is required to establish new scientific proofs for therapeutic use of such traditional medicinal plants and this by experimental work on (16 female rats). The study showed a decrease in body weight in P. granatum peel extract administered rats, may be decreasing fat absorption and storing and revealed that peel extract affect lipid profile parameters. The histopathological study no harm effects of peel extracts on liver, kidneys, gastrointestinal tract, but an ingestion in the spleen observed in the high dose treatment.