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This project has made significant conclusions that could help clinicians focus on reducing the risk of AAD. Indication of probiotics in older adults up to 64 years is warranted to reduce the risk of AAD and potential consequences, including dehydration, a possible longer length of hospital stay, and additional hospital costs. However, this project cautions on the use of probiotics to reduce the risk of AAD among patients aged 65 and above. Such a position saves the hospital and patients from incurring additional costs on an intervention that could cause more harm than benefit. As derived through evidence, probiotics among elderly patients aged 65 and above have been associated with longer AAD and prolonged hospital stay. Finally, this project has recommended the most beneficial probiotics. Clinicians can, therefore, choose depending on availability and tolerability.