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The effects of foliar spraying with KHARZA nanoparticles (NPs) and Salicylic Acid (SA) on sour orange seedlings in conditions of shade house were surveyed to get the perfect combination sour orange growth. Seedlings of the local cultivar were investigated in a factorial experiment with three replications in 2019. The results showed that spraying with NPs at a concentration of (2g. l-1) led to improve the vegetative growth characteristics, (including, plant height, stem diameter, leaves number and leaf area), chemical characteristics (including, chlorophyll and carbohydrate content) in addition to the leaf mineral content. Also, the foliar spraying with salicylic acid at a concentration of 150 mg.l-1 showed a significant superiority in the vegetative and chemical traits. From the tested interaction between NPs (2g. l-1) and SA (150mg. l-1) it was the best performing by resulting in all studied traits.