Comparative Evaluation of Liver Function with Different Grades of Lung Involvement in COVID 19 Patients

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S. Mahalakshmi, Ezhil Gurusamy, Ramadevi K.


Background:  The coronavirus disease 2019 (COVID-19) outbreak is the global pandemic causes severe acute respiratory syndrome, affects the liver in the earlier stages⁵. In our biochemistry laboratory we observed most of the covid-19 patients have deranged liver function tests commonly mixed type. Thus the main aim of our study was to analyse the association of LFT with lung involvement in symptomatic covid-19 patients with or without comorbidities.

Method:  This study is a retrospective cross sectional study, where we collected 1000 biochemical data of RT-PCR confirmed COVID-19 cases with positive CT-chest reports at the time of admission, before starting the treatment and analyzed the biochemistry data in 2 different forms. One is comparing the data of covid-19 positive cases with comorbidity to no comorbidity. Another form, the cases were classified into 4 grades based on the CT-chest, and analyzed the relationship between CT-Chest and liver function parameters.

Results: The data of 1000 cases were compared statistically. It showed a significant number of   patients with COVID-19, had abnormal liver function at the earlier state on infection. 90% of the cases have at least one abnormal liver function tests.Patients having >50% lung involvement have increased enzyme levels and decreased total protein and albumin levels, when  compared with those having <50% lung involvement

Conclusion:  In COVID-19 patients, apart from the lung involvement, extra pulmonary manifestations are also common. Liver is the most commonly affected along with lung at earlier stages.

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How to Cite
S. Mahalakshmi, Ezhil Gurusamy, Ramadevi K. (2021). Comparative Evaluation of Liver Function with Different Grades of Lung Involvement in COVID 19 Patients. Annals of the Romanian Society for Cell Biology, 3040–3055. Retrieved from