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To compare our 10 year results of retroperitoneoscopic nephrectomies (RPN) with the standard technique of open nephrectomy (ON) due to benign conditions. This article retrospectively compares the clinical results of 1050 RPN and 334 ON, respectively. The evaluation of clinical statistics included operative time, blood loss, dose of analgesic use, postoperative suggest visual analogue pain rating (day 3) and postoperative hospitalization. The basic operative period for RPN was 82.3 (13-260) min and for ON 86.9 (60-180) min. The amount of estimated blood loss was 134.4 (10-3000) ml for RPN and 195.81 (25-1000) ml for ON groups, consequently (p<0.05). Doses of analgesic medication requirement per patient was 75 (0-225) mg and 304.8 (75-1025) mg of diclofenac for RPN and ON groups respectively. The postoperative hospital stay averaged 2.71 (1-15) days for RPN and 5.60 (2-30) days for ON (p<0.05). The visual analogue pain score (VAS) at third postoperative day was 2.8 (2-5) and 5.8 (3-8) for RPN and ON groups respectively (p<0.05).Our research results show that the overall advantage of the RP approach over open surgery and the minimally invasive approach is clear.