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This study looks at pollution from heavy metals changes proteins in the liver and intestines of the freshwater fish Tilapia mossambica, as well as how many of these fish survive. Heavy metals are the most worrisome pollutants in aquatic ecosystems because they are everywhere and can be found in concentrations that can be measured. Some of the worst pollutants for fish and the aquatic ecosystem are heavy metals described in this study like mercury, cadmium, copper, lead, and zinc. Chromium is a metal that is used get into water when industries like textiles, tanneries, electroplating shops, ore mining, dyeing, printing-photographic, and medical industries dump their waste water into waterways. Heavy metals (HM) are found in small amounts in water, but their levels have gone up because of industrial waste, changes in the earth's chemistry, farming, and mining. Heavy metals from natural and human-made sources are getting into water systems all over the world. The sample size is collected 100 fish were picked out of the randomly.The findings of this study define the heavy metals that are infected or not infected in fish environments but also show how heavy metals hurt fish.