Effect of Cyclopentolate Hydrochloride 1% on Corneal Curvature in Keratoconus

Abstract

Objectives: The objective of current study is to check the effect of cyclopentolate hydrochloride 1% on corneal curvature in subjects with keratoconus.

Methodology: This comparative cross-sectional study was conducted at Ophthalmology Department of The University of Lahore Teaching Hospital in the duration of  month.  subjects of either sex with keratoconus without any pathology were selected for this study. Informed consent was taken from every individual prior to their inclusion in the study. Non-probability random convenient sampling technique was used to collect the data. After the history taking retinoscopy and subjective refraction was performed to determine the type and degree of refractive error. After that a complete ocular examination was done to rule out the subjects with keratoconus. Then the corneal curvature of each subject was measured before and after the instillation of cyclopentolate hydrochloride 1%.

Results: A total  subjects having different categories of keratoconus (Mild, moderate and severe) from the age ranged  were included in this study. There were  females and  males. The frequency of subjects with Mild Keratoconus was , with moderate keratoconus was  and with severe keratoconus was  respectively. The mean and S.D of K1 before and after cyclopentolate was 52.86±3.549 and K2 before and after cyclopentolate was  and  respectively. The results showed the significant association of cyclopentolate before and after the instillation.

Conclusion: The study results conclude that there was a significant association of cyclopentolate on corneal curvature before and after instillation of drop. Cyclopentolate hydrochloride  induced flattening of corneal curvature.