Evaluation of Antidiabetic And Antihyperlipidemic Activities of Alcoholic and Aqueous Extracts of Balanites Aegyptiaca (L.) Delile Leaves

Abstract

Background:Balanites aegyptiaca (L.) Delilebelonging to family Zygophyllaceaeis a drought resistant plant which shows its antidiabetic profile.

Aim: The aim of the present work was to study the antidaibetic and antihyperlipidemic potential of aqueous and alcoholic extracts of Balanites aegyptiacaleaves.

Methods:Acute oral toxicity studies were carried out as per OECD guidelines-423. Antidiabetic along with antihyperlipidemic activities wasevaluated by serum biochemical analysis and blood sugar levels in STZ induced diabetic mice.

Results:The alcoholic extract (250 mg/kg) revealed significant activity  in lowering blood glucose level in comparison to the aqueous extract (250 mg/kg) and Pet Ether Extract (250 mg/kg),when compared with standard drug glibenclamide (600µg/kg). On evaluation of different biochemical parameters, i.e. TGL (triglycerides), HDL, total cholesterol,LDL and VLDL level disclosed that both alcoholic and aqueous extracts has considerably  reversed the diabetes including hyperlipidemia compared to standard drug. The raised levels of SGOT, SGPT got reduced by the treatment of alcoholic extract of leaves of Balanites aegyptiaca (L.) Delile. Alcoholicextractofleaves of Balanites aegyptiaca (L.) Delilerevealed noteworthy reduction in ALP andserum bilirubin, indicated a progress in the secretary mechanism.