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Infertility is the inability to achieve clinical pregnancy over an average period of one year despite adequate regular unprotected sexual intercourse. Several types of infertility include age, smoking, alcohol, STDs, diabetes, stress, radiation therapy. Oxidative stress and carbohydrate (Alfa amylase) also plays major role for infertility and diabetic pathology. The aim of present studies was to evaluate the in vitro antioxidant and antidiabetic activity. Various plant extract has inhibitory potential enzymes linked to hypoglycemia and antioxidant activity. Antidiabetic activity was performed using Alfa amylase, Alfa glucosidase and antioxidant activity was performed using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radicals, ferric reducing/antioxidant power (FRAP) methods, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals and nitric oxide radical inhibition assay. In this study the evaluation of selected plant was performed for in vitro potential infertility (antidiabetic & antioxidant) activity. The aqueous extract of Nirgundi seed (Vitex Nigundu), Turmeric (Curcuma Longa) and Fenugreek (Trigonella foenum graecum) has showed the antidiabetic and antioxidant activity. This combination showed highest polyphenolic compounds (iso flavones and flavonoids), triterpenoid, and phenolic content which exhibited significant antidiabetic and antioxidant activity.