The significance of matrix metalloproteinase-9 and miR-126 for determination of prognosis of coronary artery disease

Abstract

The aim of this study was to evaluate miR-126 and MMP-9 expression in plasma of patients with coronary artery disease (CAD) and to assess their prognostic value.A single blood sample was obtained from 122 CAD patients at admission and 122 healthy controls. Plasma MMP-9 and miR-126 relative expression levels were analyzed byquantitative real-time polymerase chain reaction (qRT-PCR). Also, lipid profile, cardiac troponin I, and creatine kinase-MB (CK-MB) were performed.The expression of miR-126 was significantly decreased and the expression of MMP-9 was significantly increased in CAD patients. Changes in both miR-126 and MMP-9 were significantly associated with major adverse cardiac events.In conclusion, the relationship between miR-126 and MMP-9 in CAD patients might have a significant implication for prognosis of CAD.