The Effect of Clomiphene citrate with Estradiol Valerate versus Letrozole on Endometrial Thickness and Pregnancy Rate in Infertile PCOS Women

Abstract

Background: Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in infertile women. Infertility influences about 40% of PCOS women. The aim of this work was to study the effect of Clomiphene citrate plus Estradiol Valerate versus Letrozole on endometrial thickness and pregnancy rate in infertile PCOS women underwent induction of ovulation. Methods: A randomized clinical trial carried out  in Gynecology and Obstetrics Department, Faculty of Medicine, Zagazig university from March 2019 to September 2019, on 70 infertile PCO women with and were divided to 2 two groups , 35 patients patient received clomiphene citrate plus estradiol valerate and 35 patient received letrozole. Results: the results showed that endometrial thickness was high in Letrozole group B (9.7 ± 1.1) than clomiphene plus estradiol group A (8.8 ± 1.2) with a significant difference between both groups. Rate of pregnancy was higher in the Letrozole group B (45.2%) compared to clomiphene plus estradiol group A (22.9%). Conclusion: Letrozole increase the thickness of endometrial and pregnancy rate more than the Estradiol Valerate plus Clomiphene citrate in the infertile PCOS women who had abnormal endometrial thickness with Clomiphene citrate, so it is  recommended for PCOS infertile women .