evaluation of leptin serum changes in cases suffering systemic inflammatory response syndrome (SIRS) in dog

Abstract

Background and Objective: Systemic Inflammatory Response Syndrome (SIRS) is a complex set of events that may occur in animal cases because of an infectious or non-infectious cause. Therefore, the purpose of this study was to evaluate the serum changes of leptin in canine cases with systemic inflammatory response syndrome (SIRS).

Methods: The study was conducted as a prospective cross-sectional study. Of about 2500 cases admitted to the hospital, 37 canine cases admitted to the intensive care unit (ICU) were included in the study. To compare the results in the inpatient group with healthy dogs, 30 seemingly healthy dogs were selected as the healthy group and entered the study. During the study, in patient cases admitted to the ICU, hematological parameters, albumin and total protein were determined daily. Heart rate, temperature and respiratory rate were determined every 12 hours. Research data were processed in Excel and statistically evaluated in SPSS.

Results: The results showed that there was a direct relationship between increased leptin serum concentration and disease severity. There is an inverse correlation between disease severity and albumin. There is a direct correlation between disease severity and total protein. In many cases, monocytosis and neutrophilia occur. Serial and daily measurement of hematological and biochemical parameters to provide a better treatment strategy It is essential.

Conclusion: SIRS may lead to sepsis if it progresses. In such cases, the possibility of hypoalbuminemia is high. In the present study, the amount of albumin in dead dogs was significantly reduced compared to that cleared. This indicates an unfavorable prognosis of hypoalbuminemia