"Formulation Development and Evaluation of Directly Compressed Polyherbal Tablets for the Management of Infections Caused by Helminthes"

Abstract

The current study was based on the investigation protective effect of prepared direct compressed poly-herbal tablet formulation in hepatotoxicity using in-vivo animal models. Hepatotoxicity in rats was induced-by an injection of Cisplatin through intraperitoneal route of administration in rat at a dose of 7 mg/kg and DCPT at the dose 100, 300 and 500 mg/kg was injected for assessment of protective properties. AST, ALP, ALT, TB, HP, oxidative stress, pro-inflammatory cytokine, and histological alteration were measured to find the therapeutic activity of DCPT.   Rats treated with only group shows the increased levels of Proinflammatory cytokines, altered Oxidative stress, AST, ALP, ALT, TB, HP were increased because of Cisplatin induced hepatotoxicity.   After the treatment of DCPT for 7 days the level of cytokines and oxidative stress were reduced in test control group as compared to disease control group. The inhibitory action of DCPT on inflammatory responses was achieved by reducing the expressions of cytokines. Cisplatin-treated rats showed the altered structure of liver tissue; meanwhile, DCPT normalizes the structure of kidney tissue. From our findings, we conclude that DCPT has therapeutic potential in liver complications like hepatotoxicity, by inhibiting the production of Proinflammatory cytokines (i.e. TNF-α) and Oxidative stress as well as protect the rats from hepatotoxicity.