The Ethanol Extract of Red Banana Peel (M.acuminata Colla) Induce Cell Death and Inhibit Metastatic of Breast Cancer

Abstract

Breast cancer is the most common malignancy in women and the leading cause of cancer-related
death. Death from cancer is caused by metastasis to distant organs. The metastatic process is a
complex and continuous process, in which the ROS that causes oxidative stress plays a role in the
metastatic cascade. While treatment with the chemotherapy agent Doxorubicin (DOX) also causes
side effects on healthy organs. Extract ethanol Red Banana Peel (ERBP) Musa acuminata Colla
contains phytochemical compounds in the form of flavonoid, tannin, saponin, triterpenoid, and
alkaloid which are potential co-chemotherapy agents. This study aimed to determine the effect of
ERBP on the metastatic ability of breast cancer cells MCF-7 and cell death in combination with
DOX. MCF-7 Cell death was measured using the Trypan Blue Assay and metastatic ability was
measured using the Scratching Wound Healing Assay. The anticancer activity from ERBP
compounds showed that ERBP with or without DOX combination was effective in reducing viability
and inhibiting metastasis of MCF-7 cell.