The Role Of Salmonella In Progression Of Colorectal Cancer
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Abstract
Background: Colorectal cancer constituting one of the most frequently occurring malignancies. Previous studies exhibiting the cells of the host signaling manipulation by the salmonella, where chronic or carriage of the salmonella infection can triggering the cancer development among the predisposed genetically persons,
Aim: The assessments of the role of salmonella in colorectal cancer grading and staging and whether if it had a role in poor progression or good prognosis of the colorectal cancer.
Method: A 76 cases compared with nearly similar number of control by selecting their histo-pathologic specimens most of the control where excluded because of the insufficient sample size. Comparison done in Thi-Qar province- Southern of Iraq, extended from September 2020 the end of June 2021. Salmonella DNA was detected by PCR technique, and the PCR results were linked with demographic parameters such as age and gender. The data were examined by SPSS (26), P value <0.05 consider significant.
Result:Universal bacterial primer gave a positive results in 58(57.4%) of cases and only 8 (7.8%) cases of this where positive for Salmonella primers. Most cases of colorectal cancer grade were grade II -A 36.8% followed by grade II-B 19.7%. The distribution of bacterial DNA universal primer was highly amounted in Stage III (56.8%) followed by Stage II, and the salmonella DNA were also detected in higher proportion in stage III of colorectal cancer followed by Stage II and there was no case of salmonella species were detected among the cases of stage IV or stage I.
Conclusion: Bacteria including salmonella present in an important percent in the colorectal cancer tissues, which indicates the role of bacteria in the developments of cancer as confirmed by other studies. Salmonella were highly distributed among male , retired, resident in Al- Nasiriya, and married but with no significant statistical difference in their distribution within the colorectal cancer cases.