Propolis impact on Lipid Profile and Renal Function in diabetic rats

Abstract

SummeryPropolis is a honeybee product with various biological properties involving modulating lipid profile with attenuate renal lesion by its antioxidant effect. The present study was designed to evaluate hypolipidemic, renoprotective and weight improvement effects of propolisas an add-on therapy to metformin and sitagliptinin alloxan-induced diabetic rats. Single intrapertonial dose of alloxan (150mg/kg) induced diabetes. The animals was divided into seven groups (6 rats per each); group 1 (non-diabetic rats) and group 2 (diabetic rats) both received distilled water. Groups 3, 4, 5, 6 and 7 were diabetic receiving 100mg/kg metformin, 100mg/kg propolis, 50 mg/kg sitagliptin, 100mg/kg metformin + 50mg/kg sitagliptin, and 100mg/kg propolis +100mg/kg metformin + 50mg/kg sitagliptin respectively. After 21 days of alloxan injection, there were significant elevation in the levels of Total cholesterol, Triglyceride, LDL-cholesterol, Cardiac-risk ratio, blood Urea nitrogen and Creatinine, with significant reduction in HDL-cholesterol, Cardioprotective index and animals body weights. On other hand, oral daily supplementation with propolis to diabetic rats improved lipid profile parameters, renal function and body weight.The findings of this study were significant (P-value<0.05). In conclusion, propolis possesses hypolipidemic and renal protective activitieswith good protection effect of body weight, so it was delay the occurrence of diabetic complication