Study of the Effect of Fluconazole, Alcohol Extract Curcumenind Nano Curcumenon Candida Albicans Isolated From Cancer Patients

Abstract

Candidosis or candidiasis is the most common fungal infection in the oral cavity and is caused by Candida species. The most common species in infected and healthy mouths is Candida albicans.

During the period from September to November 2020, a total of 150 clinical samples were collected from Middle Euphrates Cancer Center in AL Najaf Governorate, which included swabs from the mouth. The Cultivation and identification methods of Candida albicans isolates were based on   the morphological, cultural and biochemical characteristics, beside to the confirmative systems such as chromagar medium. And determine virulence factors (lipase  , phospholipase and  exopolysaccrid production)tube and in microtiter plate). Study the effect of fluconazole, alternative material (alcoholic extract curcumin&nanocurcumin ) on growth C. albicans and their virulence factors. This research seems to be, Fluconazole and nanocurcumin are affected on culture and virulence factors of Candida albicans while alcoholic extract curcumin are affected on virulence factors only.