The Influence of Potassium Iodide and Perchlorate on the Process of Thyroid Hormones Secretion

Abstract

        The effect of iodide and potassium perchlorate on the secretion of T3 and T4, the level of cAMP and the number of intracellular drops of colloid in the thyroid gland after stimulation with thyroid-stimulating hormone was studied. It was found that an excess of iodide suppresses the secretion, and the introduction of perchlorate prevents the inhibitory effect of iodide. The results support the opinion about the dependence of the adenylate cyclase system of the thyroid gland on the concentration of organic iodine.