Expression of non-thyroid specific autoantibodies among autoimmune thyroiditis patients in Iraq

Abstract

Autoimmune thyroid disease (AITD) are the most common organ specific autoimmune disorders affecting 5-10% of populations. AITD is characterized by the presence of autoantibodies to thyroid gland component as anti-Tg and anti-TPO, also the presence of autoantibodies of other diseases as dsDNA. Aim of study: Our study aimed to determine the correlation of AMA and dsDNA autoantibodies with Iraqi AITD patients, also to detect the hormonal changes among patients groups. Materials and methods: Ninety (90) blood samples were collected from patients suffering thyroid gland disease in both gender whose age ranged 15-65 years, for the period from September to the end of November 2020 from Baghdad teaching hospitals, samples divided into 60 patients groups and 30 healthy control. All samples were tested to evaluate the levels of TSH and T3 hormones, AMA and dsDNA autoantibodies by using the ELISA technique. The data obtained were subjected to analysis by using statistical package of social science (SPSS) version 26.0. Results:  the highest rate was noticed in the autoimmune hyperthyroidism group (56.81%) to (43.18%) in hypothyroidism group. The percentage rate of incidence was in (15-44) years more than (45-65) years in both autoimmune hyperthyroidism and autoimmune hypothyroidism. Females represent about 77.27% of studied groups, also our result indicate that non-organ specific autoantibodies (AMA and anti-ds DNA) levels are elevated in patient with autoimmune thyroiditis compared with healthy control group. Conclusion: From the revealed data we conclude that patients with AITD are prone for other autoimmune disease.