Effect of grape seed extract as a novel endodontic irrigant

Abstract

The goal of primary endodontic treatment is to promote a desired root canal disinfection, depreciating bacterial load to levels compatible with peri-radicular tissue healing and preventing microbial re-colonization of the treated canal. During the cleaning and shaping stages, endodontic instruments and irrigant solutions are used to reduce bacterial contamination in the root canal. Sodium hypochlorite (NaOCl) has been extensively recommended as an irrigant for the chemomechanical preparation of root canals due to its ability to dissolve both necrotic and vital tissues and its antimicrobial properties. However, when used in higher concentration, it is caustic and toxic to vital tissues when passes through apical foramen, decreases the mechanical properties of dentin. Grape seed extract (GSE) is antimicrobial, antifungal; therapeutically, it is antioxidant, immunodilators, antimutagens, and also has biostability and dentin biomechanical properties. Hence, various articles have compared NaOCl and GSE as endodontic irrigant and proved GSE is a promising endodontic irrigant. This review is done to prove the effect of GSE as a promising endodontic irrigant.