Immunological and neurohormonal changes in women with multiple sclerosis during pregnancy and disease outcomes

Abstract

The problem of demyelinating diseases of the nervous system, in particular multiple sclerosis (MS), is currently relevant not only all over the world, but also in Uzbekistan, affects young people, contributing to an increase in disability and mortality. In recent years, MS has usually acquired an upward trend and a social character, not only due to an increase in the number of new cases, but also due to a deterioration in the quality of life of patients, rejuvenation of persons with MS.
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) that predominantly affects young women of reproductive age and leads to the gradual development of permanent disability [1,15]. The first report on MS was published in 1835 by the French physician J. Cruvellier, and in 1868 its clinical symptoms were first identified by the French neurologist Jean-Martin Charcot, initiating serious research in this area [19].