Association of Toll-Like Receptor (TLR-4) Gene Polymorphisms in Diabetic Kidney Disease: Iraqi Cohort Study

Abstract

Aims: This study aims to examine the role of TLR-4 gene polymorphisms in Type 2 Diabetes Militias (T2D) and its complications. 400 T2D patients were enrolled in this study. Patients were distributed into three clinical groups: normal albuminuria (n=145), microalbuminuria (n=162), and macroalbuminuria (n=93) groups. Multi-nominal logistic regression analysis applied to study genotype and allele frequencies for gene polymorphism,for the (+194C/T). The genotypic frequencies of Micro albuminuria group were (n=116, 71.4%) normal CC and (n=32 20.0) heterozygous CT. Mutant homozygous was found inTT (n=14, 8.6%). The results in Normo albuminuria group demonstrate (n=73, %50.0) wild type CC, (n=45, 31.25%) heterozygous CT and mutant homozygous TT 18.75% (n=27). The odds ratio for the 194CT was 1.27; p=0.56. The TLR-4 gene of Thr399Ile polymorphism was correlated to the early onset of diabetic kidney disease, while Asp299Gly polymorphism of the TLR-4 gene seems to act as a protective factor for diabetic nephropathy.