Improvement of the Method of Plasmosorption in Liver Insufficiency on the Background of Mechanical Jaundice and Estimation of its Efficiency in Experiment
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Abstract
To enhance the sorption effect during extracorporeal detoxification in order to correct hepatic failure against the background of obstructive jaundice, a method of plasma sorption based on the use of a new domestic carbon nanoporoushemosorbent in combination with laser irradiation of blood plasma is proposed. High detoxification activity was noted during 2 sessions of plasma sorbent both with a carbon sorbent (a decrease in total bilirubin from 213.8 ± 8.0 to 100.5 ± 6.1 μmol / l), and when using domestic carbon hemosorbent (from 217.3 ± 6.6 to 90.3 ± 5.4 μmol / L), which significantly (p <0.05) differed from the control without plasmasorption, a similar picture was obtained for the parameters of urea, creatinine and ammonia, the values of which were normalized much faster (p <0.05) after the first session of extracorporeal detoxification.