The Role of Mother-Placenta-Fetus System's Protection Mechanisms Disturbance in Delayed Fetus Growth and Development

Abstract

The influence of the content of the balance of cobalt, nickel and lead on the mother-placenta-fetus system in children born with low birth weight was studied. Determination of trace elements was carried out in the blood serum and in the placenta of 30 pregnant women and their newborns. The comparison group consisted of 30 healthy women and their 30 healthy full-term newborns with normal weight. In the blood serum of low-birth-weight infants, the content of cobalt was significantly reduced, while the content of lead and nickel was, on average, 2 times higher in comparison with newborns with normal weight. It has been proven that an excess and imbalance of toxic microelements in a woman's body, dysfunction of the placenta lead to an imbalance of these microelements in the body of the fetus and the newborn, a violation of the conditions for fetal development, contributes to a delay in weight gain and the birth of children with low weight..