Relationship between Vitamin D Level in Plasma of Pregnant Women and Prediction of Gestational Diabetes Mellitus

Abstract

Background:Vitamin D deficiency during pregnancy has been associated with adverse outcomes in pregnant women, such as GDM, urinary tract infection, preeclampsia, and cesarean delivery. Furthermore, infants born to mothers with lower vitamin D levels have been found to have elevated risk of small for gestational age, low birth weight, cardiovascular disease, respiratory illnesses, and type 2 diabetes mellitus. The aim of this work was to assess the relationship between vitamin D Level in Plasma of Pregnant Women and Prediction of Gestational Diabetes Mellitus. Methods:A case control study was conducted at Gynecology and Obstetrics Department, Zagaziguniversity during the period from August 2020 until April 2021. It included a total of 104 pregnant women. Clinical and obstetrical data were gathered, Serum 25(OH) vitamin D3 total level was measured. Results: There was a statistically significant difference between GDM and control groups in the vitamin D level. The GDM group had significantly lower vitamin D than the control group. Almost two-thirds of the GDM group had deficient vitamin D levels, and only 7.7% had sufficient vitamin D levels. while there was no statistically significant association between Vitamin D level and obstetric history , laboratory data of GDM group. Conclusions:There is inverse association of vitamin D status with gestational diabetes risk.