Synthesis and Characterization of Acelofenac Sustained Release Microspheres Using Madua Rice Starch Powder for Gastro-retentive Drug Delivery System

Abstract

The purpose of the study is to extract the starch through mandua rice powder and prepare the floating microsphere for targeted delivery of aceclofenac. The microspheres were prepared by using to Technique Single emulsion use polymer and drug. According to method drug and polymers are accurately weighed and transfered to a 100 ml beaker, the mixture is then heat over hot plate at 400 temperature for 30 min, a clear gel was obtained. Then prepare a mixture of 100 ml paraffin liquid light (75 ml) and paraffin liquid heavy (25 ml) in a 500 ml beaker and keep the beaker over a hot plate in a water bath at temperature 60 °C, add the freshly prepared gel in this mixture and stirrer the mixture by using mechanical stirrer at 2200 rpm, after 15 min added 5 drops of span 80 then after 30 min add epichlorohydrin according to formula and the mixture was continuously stirrer for 5 hours. Then the solution was stayed for 24 hours, after that we get freshly prepared floating microsphere which were filter with petroleum ether. Preformulation studies were carried out for drug and polymers. The microsphere formulations were examined for their in vitro characteristics including percentage yield, drug content, X-rd, SEM, DSC and FTIR. The % yield of batches FM1, FM6 and FM10 were found best.  It was calculated that the batch no FM1, FM6 and FM10 has best entrapment efficiency. FM1 has the best release of all the formulations, we have seen that FM1 was the best floating microspheres formulation prepared using madua rice starch powder. The FTIR, XRD, SEM and microscopic study of microspheres confirms that microspheres using madua rice can be prepared and has better compatibility and physical appearance. The dissolution study of floating microspheres of aceclofenac using madua rice shows better release of the drug. By using pharmacokinetic modeling method it was confirmed that the Makoid-Banakar and Weibull method were best fit model for the release study of the drug. Thus it was concluded , that the microspheres prepared have good gastric retention time, Microspheres of aceclofenac reduces the side effect of the drug. Microspheres are single unit dosage forms so dose dumping can be overcome. Madua is a natural polymer so it has no side effects and can be used in the preparation of microspheres.