Possibilities of Serological Diagnosis of Atrophic Processes of the Gastric Mucosa

Abstract

The association between HP infection and CAH development suggested by the Correa cascade is supported by several cohort studies. To diagnose and determine the severity of atrophy at the Center, patients underwent a serological analysis by ELISA method in the clinical and biochemical laboratory of the State Institution "RSNPMCT and MR". Analyzes were taken in 69 (58.5%) patients, including 35 (50.7%) with CAH, 34 (49.3%) with CNG. Analysis of the non-invasive indicator of the level of pepsinogens in patients with CAH determined that severe atrophy was detected in 20%, moderate atrophy - 42.9%, weak atrophy - 34.3%, and no atrophy was found in 2.9% of patients. The pepsinogen parameters in patients with CNG were also as follows: PG I was within 95.4 ± 7.2 μg / L, PG II 14.5 ± 1.3 and PGI / PGII 6.6 ± 0.2. Pepsinogen values ​​were more pronounced in patients with CAH: with a pronounced degree of atrophy, PGI was 8.7 ± 0.1 μg / l and PGI / PGII was 1.1 ± 0.1; with moderate atrophy 16.6 ± 0.9 μg / l and 1.6 ± 0.1; with mild atrophy 27.2 ± 1.5 and 2.3 ± 0.2, respectively.