Evaluatingthe Outcome of Total Intravenous Anesthesia and Single Drug Pharmacological to Prevent Postoperative Vomiting: Systematic Review and Meta-Analysis

Abstract

Background and aim: the aim of present systematic review and meta-analysis was evaluate the outcome of total intravenous anesthesia and single‐drug pharmacological to prevent postoperative vomiting in children and adult. Method:From the electronic databases, PubMed, Cochrane Library, Embase have been used to perform a systematic literature until May 2021. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included. Moreover risk ratio with 95% confidence interval (CI), fixed effect model and Mantel-Haenszel method were calculated. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata). Result:A total of 224 potentially relevant titles and abstracts were found during the electronic search. Finally, nine studies required for this systematic review. Risk ratio of postoperative nausea and vomiting in adult and children was 0.03 (RR, 0.03 95% CI -0.22, 0.27. P= 0.81) and -0.07 (RR, -0.07 95% CI -0.30, 0.17. P= 0.59), respectively.
Conclusion: Present systematic review and meta-analysis showed there was no statistically significant difference between total intravenous anesthesia and single‐drug pharmacological to prevent postoperative nausea and vomiting in children or in adults. Finally, it can be concluded that total intravenous anesthesia had equally effective compared with Single pharmacological prophylaxis to reduce PONV in children and adults.