Study of Expression of KAI-1 in Breast Carcinoma

Abstract

Background –The KAI1 gene, which is also called as CD82, its a metastasis suppressor gene  whichis indicated as development of disease of certain solid tumors, involving breast cancer. In normal breast tissue and non-invasive breast cancer, KAI1 protein levels are elevated and decreased in infiltrating breast tumors by comparison. The level of KAI1 protein is inversely proportionalto the  potentialof metastasis of cancer cells of breast. In this studyexpression of KAI1 in breast cancer is done by immunohistochemical technique and to assess the relationship between the KAI1 protein expression with Nottingham Prognostic Index and individual parameters of Nottingham prognostic index.

Objectives -   To assess the relationship between the KAI1 protein expression level with Nottingham Prognostic Index and individual parameters of Nottingham prognostic index.

Methods – The present study is an observational, cross sectional and retrospective study to be conducted for a duration of two years in the Histopathology and Immunohistochemistry division of the Pathology department, JawaharlalNehruMedicalCollege, Sawangi (Meghe), in coordination with the Department of General Surgery, AcharyaVinobaBhaveRuralHospital, Sawangi (Meghe). In this study, 40-50 Carcinoma of Breast caseswho have undergone ModifiedRadical Mastectomy will be taken. The Nottingham Prognostic Indexother individual parameters of Nottingham Prognostic Index will be determined in each case and their correlation will be studied through a well-tabulated master chart.

Results -The observations will be depicted in a well-tabulated master chart.

Conclusion - Conclusion will be drawn from the results obtained from the study.