Study of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma

Abstract

Background -An significant category of neoplasia consists of head and neck tumors and its occurrence rises day by day. More than 95 per cent oral cancers aresquamous type. It is a major health problem and a chief cause of death as well. For detection of cancers, immunohistochemistry is generally used.Keratins are intermediate filaments thar are primarily expressed in epithelial cells. In mechanical support and Cytoskeleton formation it plays an important role that is crucial for cellular stability and integrity. The present study is designed with an aim to correlate Cytokeratin 17 expression by immunohistochemistry with histological grade of oral squamous cell carcinoma which predicts aggressiveness of the tumor and thus helps in early diagnosis and treatment.

Objectives -   To evaluate Cytokeratin 17 expression and assess the correlation with the histological grade in oral squamous cell carcinoma.

Methods-This study is an observational, retrospective and cross-sectional type. The study will be carried for two years from October 2020-September 2022 in the Histopathology division and Immunohistochemistry section in the Pathology Department, Jawaharlal Nehru Medical College (JNMC) in coordination with Department of surgery, Department of Otorhinolaryngology, Oral and Maxillofacial surgery Department, Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi(Meghe), Wardha, Maharashtra, India. To evaluate Cytokeratin 17 expression by immunohistochemistry and to correlate Cytokeratin 17 expression with histological grade of oral squamous cell carcinoma immunostaining for Cytokeratin 17 will be carried out.

Department of Oral Pathology, SharadPawar Dental College.

Results -The observations will be tabulated.

Conclusion - Conclusion will be drawn from the results obtained from the study.