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The immobilization of proteases can lead to several approaches like easy handling and recovery from a particular reaction medium and can be reused the enzyme in the continuous processing. Proteases also are being used in several application that is treatment of cancer, on antitumoral cells , for swelling and immune modulation like disorders and for digestive issues. Proteases have ability to survive in extremely high critical conditions that is why proteases are being used in industrial level as known as such crucial enzymes. Covalent binding can be used to immobilized the Proteases enzymes through an irreversible enzyme immobilizations.[ Ali et al., 2016] To maintaining the stability of an enzymes is the most important part of the immobilization of an enzyme, it may create several problematic situations and sometimes halt to process too. Matrix metalloproteinases (MMPs) are also protease types, which are growing with their multiple uses. Several articles have been evidence for the MMPs roles. This review discuss with the structure and functions of the different MMPs. Mainly, the crisp points of the MMPs is signal transduction pathways, along with MMPs non- matrix degradation functions, in case of apoptosis. Inspite with MMPs complicated role with its physiology, we are focusing with therapeutics target. Its specificity to the inhibition is little bit difficult, but homeostasis play a great role in its functionality.