Thyroid Functions in CKD: A Single Center Experience

Abstract

There are several interactions between thyroid and kidney functions in each other organ's disease states. Thyroid hormones affect renal development and physiology. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and the glomerular filtration rate (GFR). The present study aims to find out the status of thyroid dysfunction in patients with chronic kidney disease and to correlate between thyroid dysfunction and severity of renal disease in terms of laboratory parameters and zulewski’s clinical scoringsystem. Total 100 patients (n=100) were included in the study. The association between thyroid function and Zulewski’s clinical scoring system was evaluated in our study, which was not significant statistically. (χ2 = 0.1852, p > 0.05).This indicates lesser utility of Zulewski’s clinical scoring system for assessment of thyroid dysfunction. These two disorders, chronic kidney disease and thyroid are managed by specific pharmacological agents, need titration by testing and by clinical signs. A physician must keep the possibility of co-existing chronic kidney disease and thyroid disorders.